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Sitagliptin: DIGOXIN: There was a slight increase in the area under the curve (AUC, 11%) and mean peak drug concentration (Cmax, 18%) of Digoxin with the coadministration of 100 mg Sitagliptin for 10 days. Patients receiving digoxin should be monitored appropriately. No dosage adjustment of digoxin or sitagliptin is recommended.
Metformin Hydrochloride: Use of biguanide concomitantly with other drugs that lower blood-glucose concentrations increases the risk of hypoglycaemia, while drugs that increase blood-glucose concentrations may reduce the effect of biguanide therapy. In general, fewer drug interactions have been reported with biguanides than with sulfonylureas. Alcohol may increase the risk of lactic acidosis as well as of hypoglycaemia. Care should be taken if biguanides are given concomitantly with drugs that may impair renal function.
